タシロ　ミツル   田代　充    所属   理工学部 総合理工学科    職種   教授
言語種別	英語
発行・発表の年月	2026/02
形態種別	学術雑誌
査読	査読あり
標題	Practical NMR screening strategy for analyses of fluorinated compounds bound to proteins
執筆形態	共著
掲載誌名	Research on Chemical Intermediates
掲載区分	国外
出版社・発行元	Springer Nature
担当範囲	NMR測定、解析、執筆
担当区分	責任著者
著者・共著者	K. Furihata, S. Tsukada, A. Tsutsui, M. Tashiro
概要	NMR screening methods based on 19F NMR experiments, such as 19F{1H} saturation transfer difference, 19F spin-spin relaxation time and 19F diffusion coefficients, were evaluated for assessing complex formation for fluorinated compounds. The quantitative ligand-observed 1H NMR assay was also carried out to determine Kd values using transverse relaxation rate R2 and diffusion coefficients. The combinational analysis using various 19F/1H NMR experiments was shown to be an effective means of assessing complex formation for fluorinated compounds.